Fives-Lille supplied the ten freight locomotives 161 DE 1 to 10, which again consisted of two halves. In each half of the locomotive, three powered axles were mounted in the frame, which, like the 161 CE, were supplemented by a movably mounted leading axle. The weight distribution was designed in such a way that the leading axles each had to carry less than ten tonnes and therefore more adhesion mass was available. Instead of platforms at the ends of the locomotives, there were smaller hoods, while the doors were attached to the sides. When the locos were taken over by the SNCF, they became the 1CC1 3801 to 3810. The last examples remained in service until 1973.

A special feature of the series came about during the war, when 1CC1 3805 fell victim to a bomb attack in Modane. Only one half of the locomotive was badly damaged, while the other remained largely intact. It was not until 1949 that the intact half was refurbished and used as an independent locomotive with the number 1C 1001 in shunting operations in Saint-Jean-de-Maurienne. The contact shoes for the third rail were removed so that the locomotive could only work under the catenary. The continuous output was increased to 1,070 kW and use ended in 1966.