The class 350, 360 and 380 multiple units were primarily developed for use under 25 kV AC from the overhead line. The first trains in this series were 21 class 360/1 four-car trains, delivered to First Great Eastern in 2003 and handed over to Greater Anglia in 2012. They were replaced by class 720s in 2020 and 2021 and have since been used by East Midlands Railway on the Midland Main Line. In return, they've received a smaller passenger capacity and a top speed of 110 mph. The class 360/2 are similar trains that have been used by Heathrow Connect between London Paddington and Heathrow since 2004 and have been operated by TfL Rail from 2018. However, they were replaced by the Class 345 and put into storage by September 2020.

The class 350 designates four-car trains that are used on faster regional connections. The first 30 sets were created from the 120 cars that were actually intended for the class 450/2 of the South Western Railways. They can be used with 25 kV AC from the overhead line as well as with 750 V DC via the third rail and have been approved for 110 instead of 100 mph since 2012. The total number of class 350 trains was brought to 87 with the class 350/2. These can only be used in the DC network and have also been allowed to run 110 mph since 2018. Very similar to the classes 350 and 360, but only equipped for use with AC via pantographs, is the class 380. Twenty-two three-car class 380/0 trains and 16 four-car class 380/1 trains were used for the non-realised Glasgow Airport Rail Link ordered and delivered between 2009 and 2011. They have a new, futuristic design at the front and are provided with gangways. These are now used by Abellio ScotRail on other routes in Scotland.